Inositol phosphate kinases in the eukaryote landscape
نویسندگان
چکیده
منابع مشابه
How versatile are inositol phosphate kinases?
This review assesses the extent and the significance of catalytic versatility shown by several inositol phosphate kinases: the inositol phosphate multikinase, the reversible Ins(1,3,4) P (3)/Ins(3,4,5,6) P (4) kinase, and the kinases that synthesize diphosphoinositol polyphosphates. Particular emphasis is placed upon data that are relevant to the situation in vivo. It will be shown that catalyt...
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In mammals, many cellular stimuli evoke a response through G protein activation of phospholipase C, which results in the lipid-derived production of inositol 1,4,5-trisphosphate (IP(3)). Although it is well established that IP(3) is converted to numerous inositol phosphates (IPs) and pyrophosphates (PP-IPs) through the action of up to six classes of inositol phosphate kinases (IPKs), it is not ...
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Genomic studies have revealed the presence of Ser/Thr kinases and phosphatases in many bacterial species, although their physiological roles have largely been unclear. Here we review bacterial Ser/Thr kinases (eSTKs) that show homology in their catalytic domains to eukaryotic Ser/Thr kinases and their partner phosphatases (eSTPs) that are homologous to eukaryotic phosphatases. We first discuss ...
متن کاملPhosphatidylinositol and inositol phosphate metabolism.
The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety of signal transduction processes. These important actions have infiltrated so many areas of cell biology...
متن کاملInositol polyphosphate kinases: regulators of nuclear function.
Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosp...
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ژورنال
عنوان ژورنال: Advances in Biological Regulation
سال: 2021
ISSN: 2212-4926
DOI: 10.1016/j.jbior.2020.100782